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PPI Therapy related information | PPI Therapy SYMPTOMS: Learn about the symptoms of acid reflux disease DRUGS: Common medications used to treat heartburn TREATMENT: Lifestyle changes, medication, and surgeryoptions Last Updated: 10/29/2004 Related Encyclopedia • Abdominoplasty • Acidophilus • Adhesions • Amebiasis More... Related Healthscout Videos eFeed: Teaching Toddlers How to Eat Home Remedies: All Natural Antibiotics Meals and Multitasking: Bad Combo Eating Away Arthritis Symptoms More... Related Animations • GERD More... Related Drug Information • Aciphex • Nexium • Prevacid • Prilosec More... Related News Articles • Health Tip: Spot the Symptoms of GERD • Health Tip: Encourage Your Kids to Choose Healthy Snacks • Folic Acid, Vitamin B12 Linked to Cancer • Bad Cholesterol Levels Drop, More Screening Needed More... PPI Therapy The inner surface of the stomach is formed into numerous gastric pits from which acid is secreted. The cells lining the gastric pits are: Mucous neck cells which secrete mucous, The G cells which secrete gastin The parietal cells which secrete hydrochloric acid The proton pump present in parietal cells is responsible for acid secretion The proton pump is located in the luminal side of the parietal cell Parts: Proton pump Proton Potassium ATP The proton pump actively transports proton into the stomach lumen and potassium back to the parietal cell with hydrolysis of ATP. Proton pump inhibitors are drugs which reduce acid secretion of the stomach. The drug passes unchanged through the stomach and is absorbed in the small intestine. The drug binds irreversibly to the proton pump and prevents the active transport of protons. This dramatically decreases the acid secretion of the stomach.