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Eosinophilic granuloma - X-ray of the skull Respiratory system

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Histiocytosis

Alternative Names: Eosinophilic granuloma; Pulmonary histiocytosis X; Nonlipid reticuloendotheliosis; Pulmonary langerhans cell granulomatosis; Hand-Schuller-Christian disease; Letterer-Siwe disease; Langerhans cell histiocytosis Symptoms: The symptoms that affect children and adults are listed below, although there can be some overlap. Text Continues Below Adult: Cough Shortness of breath Chest pain Fever Weight loss General discomfort, uneasiness, or ill feeling (malaise) Increased amount of urine output Thirst and increased drinking of fluids Bone pain Rash Children: Failure to thrive Weight loss Irritability Fever Seborrheic dermatitis of the scalp Abdominal pain Jaundice Vomiting Limping Thirst and frequent urination Short stature Delayed puberty Mental deterioration Headache Dizziness Seizures Increased eyeball protrusion Swollen lymph glands Generalized rash (petechiae or purpura) Chronically draining ears Possible bone pain Signs and tests: Adult: Chest x-ray Bronchoscopy with biopsy showing typical X bodies in histiocytes Pulmonary function tests Children: Bone x-ray showing punched-out appearance of bone lesions Skeletal survey x-ray (x-rays of the entire skeleton) to determine the degree of bone involvement Biopsy of skin to check for the presence of Langerhans cells Bone marrow biopsy to check for the presence of Langerhans cells Complete blood count (CBC) Other tests as clinical symptoms direct

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