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Chronic obstructive pulmonary disease
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| Chronic obstructive pulmonary disease |
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Definition:
Chronic obstructive pulmonary disease (COPD) is a group of lung diseases involving limited airflow and varying degrees of air sac enlargement, airway inflammation, and lung tissue destruction. Emphysema and chronic bronchitis are the most common forms of COPD. Alternative Names:
COPD; Chronic obstructive airway disease; Chronic obstructive lung disease
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Causes, incidence, and risk factors:
The leading cause of COPD is smoking, which can lead to the two most common forms of this disease, emphysema and chronic bronchitis. Prolonged tobacco use causes lung inflammation and variable degrees of air sac (alveoli) destruction. This leads to inflamed and narrowed airways (chronic bronchitis) or permanently enlarged air sacs of the lung with reduced lung elasticity (emphysema). Between 15% and 20% of long-term smokers will develop COPD. Other risk factors for COPD are passive smoking (exposure of non-smokers to cigarette smoke from others), male gender, and working in a polluted environment. Rarely, an enzyme deficiency called alpha-1 anti-trypsin deficiency can cause emphysema in non-smokers.
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