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Cirrhosis
Definition:
Cirrhosis is the result of chronic liver disease that causes scarring of the liver (fibrosis - nodular regeneration) and liver dysfunction. This often has many complications, including accumulation of fluid in the abdomen (ascites), bleeding disorders (coagulopathy), increased pressure in the blood vessels (portal hypertension), and confusion or a change in the level of consciousness (hepatic encephalopathy). Alternative Names:
Liver cirrhosis Text Continues Below
Causes, incidence, and risk factors:
Cirrhosis is caused by chronic liver disease. Common causes of chronic liver disease in the US include hepatitis C infection and long-term alcohol abuse. (See Alcoholic liver disease.) Hepatitis C is now the most common reason for liver transplantation in the US. Other causes of cirrhosis include hepatitis B, medications, autoimmune inflammation of the liver, disorders of the drainage system of the liver (the biliary system), and metabolic disorders of iron and copper (hemochromatosis and Wilson's disease).
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