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Alcoholic liver disease

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Alcoholic liver disease

Definition:

Alcoholic liver disease involves an acute or chronic inflammation of the liver induced by alcohol abuse. See also cirrhosis.

Alternative Names:
Liver disease due to alcohol; Cirrhosis or hepatitis - alcoholic; Laennec's cirrhosis

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Causes, incidence, and risk factors:

Alcoholic liver disease usually occurs after years of excessive drinking. The longer the duration of alcohol use and the greater the consumption of alcohol, the greater the probability of developing liver disease. Acute alcoholic hepatitis can result from binge drinking, and may be life-threatening if severe.

Malnutrition develops as a result of empty calories from alcohol, reduced appetite, and malabsorption (inadequate absorption of nutrients from the intestinal tract). Malnutrition contributes to liver disease.

The toxicity of ethanol to the liver, individual susceptibility to alcohol-induced liver disease, and genetic factors also contribute to the development of alcoholic liver disease.

Alcoholic liver disease does not affect all heavy drinkers, and women may be more susceptible than men. Drunkenness is not essential for the development of the disease.

Changes start within the liver as inflammation (hepatitis) and progress to fatty liver and cirrhosis. Cirrhosis is the final phase of alcoholic liver disease. Symptoms may not be present until the disease is relatively advanced.

Serious complications are associated with advanced disease such as alcoholic encephalopathy (damage to brain tissue) and portal hypertension (high blood pressure within the liver).

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