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There is no cure for hepatitis C.
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Some patients with hepatitis C benefit from treatment with interferon alpha or a combination of interferon alpha and ribavirin.
Interferon alpha is given by injection just under the skin and has a number of side effects, including flu-like symptoms, headaches, fever, fatigue, loss of appetite, nausea, vomiting, depression, and thinning of hair. Treatment with interferon alpha may also interfere with the production of white blood cells and platelets.
Ribavirin is a capsule taken twice daily, and the major side effect is severe anemia (low red blood cells). Ribavirin also causes birth defects. Women should therefore avoid pregnancy during and for 6 months following treatment.
Recently, a version of interferon alpha with a longer half-life (pegylated interferon alpha) was introduced, and the longer half-life means the injections are taken weekly instead of the three times a week with standard interferon alpha. Pegylated interferon alpha and ribavirin lead to a sustained response in approximately 50% of patients.
A sustained response means that the patient remains free of hepatitis C virus 6 months after stopping therapy. Approximately 40% of patients with genotype 1 infection will respond.
Rest may be recommended during the acute phase of the disease when the symptoms are most severe. All patients with hepatitis C should be immunized against hepatitis A and B.
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