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Muscular atrophy
Muscular atrophy


Hyperkalemic periodic paralysis

Alternative Names:
Paramyotonia congenita; Periodic paralysis - hyperkalemic

Treatment:

The goals of treatment are relief of acute symptoms and prevention of further attacks.

Text Continues Below



Attacks are seldom severe enough to require emergency treatment. However, weakness can become worse with repeated attacks, so treatment to prevent the attacks should occur as soon as possible.

Glucose or other carbohydrates (sugars) given during an attack may reduce the severity. Intravenous calcium or diuretics such as furosemide may need to be given to stop sudden attacks. Intravenous glucose and insulin cause potassium to move into the cell and may reduce weakness without a loss of total body potassium.

A high-carbohydrate diet may be recommended.

Acetazolamide, a medication that prevents attacks of familial periodic paralysis, is also effective in preventing attacks of hyperkalemic periodic paralysis. Thiazide diuretics such as chlorothiazide are also effective and have fewer side effects than acetazolamide.



Expectations (prognosis):

Sometimes attacks resolve later in life on their own. However, chronic attacks generally result in progressive muscle weakness that is present even between attacks.

Hyperkalemic periodic paralysis responds well to treatment. Treatment may prevent, and may even reverse, progressive muscle weakness.



Complications:
  • Kidney stones (a side effect of acetazolamide)
  • Heart arrhythmias during attacks (rare, not fatal)
  • Difficulty breathing, speaking, or swallowing during attacks (rare)
  • Progressive muscle weakness


Calling your health care provider:

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