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The best treatment is rapid reduction in thyroid hormone levels. Potassium should also be given during the attack. It is preferred that potassium be given by mouth, but if weakness is severe, intravenous potassium may be necessary. (Note: intravenous potassium should be given only if kidney function is adequate and if the person is monitored in the hospital.)
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Weakness that involves the muscles used for breathing or swallowing is an emergency and patients must be taken to a hospital. Dangerous heart arrhythmias may also occur during attacks.
A diet that is low in carbohydrates and salt may be recommended to prevent attacks. In addition, medications called beta-blockers may reduce the number and severity of attacks while hyperthyroidism is brought under control.
Acetazolamide, a medication that is effective in attack prevention with familial periodic paralysis, is usually not effective with thyrotoxic periodic paralysis.
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