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Medical Health Encyclopedia
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Hypothalamus hormone production
Hypothalamus hormone production


Cushing’s syndrome - exogenous

Alternative Names:
Cushing's syndrome - corticosteroid induced; Corticosteroid-induced Cushing's syndrome; Iatrogenic Cushing's syndrome

Treatment:

The suggested treatment is slow withdrawal of corticosteroid therapy under medical supervision. In situations where the medication cannot be discontinued because of the underlying disease (for example, if steroids are needed to treat severe asthma), every effort should be made to reduce the possibility of developing complications.

Text Continues Below



Excess glucocortoids can raise blood sugar and cholesterol levels, and increase bone loss.

  • High blood sugar should be treated aggressively with diet, oral medications, or insulin.
  • High cholesterol should be treated with diet or medications.
  • Most experts recommend treating patients who will be on steroids for longer than 4-6 weeks in with medication to prevent bone loss (bisphosphonates like alendronate or risedronate). This will reduce the risk of fracture.


Expectations (prognosis):

The effects of adrenal atrophy caused by chronic drug administration should be reversible by withdrawing the drug.



Complications:
  • Cushing's syndrome symptoms may cause persistent discomfort.
  • Steroids may cause diabetes and high cholesterol levels. If left untreated, both of these complications can increase the risk of heart attacks. Untreated high blood sugar over many years can cause damage to the eyes, kidneys and nerves.
  • Cushing's syndrome may also lead to weak bones (osteoporosis) and increase the risk of fracture.
These complications can generally be prevented with proper treatment.

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