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Circulatory system

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Necrotizing vasculitis

Alternative Names: Vasculitis - necrotizing Symptoms: Skin lesion Papule (small, solid, and raised lesion) Lesions red or purple (purpuric) Lesions on the legs, hands, or other areas Fingers that change color (blueness of the fingers or toes) Infarction (tissue death due to lack of oxygen) Pain or tenderness in the area Redness (if superficial area) Non-healing ulcers Joint pain (such as knee pain, elbow pain) Abdominal pain Pain, numbness, tingling in an extremity or any area Changes or decrease in function of an extremity or any area Fever Additional symptoms that may be associated with this disease: Weakness Swallowing difficulty Speech impairment Leg pain Muscle contractions Muscle atrophy Movement difficulty Painful menstruation Hoarseness or changing voice Fatigue Pupils that are different size Eyelid drooping Note: Symptoms vary depending on the location of the affected vessels. Signs and tests: Text Continues Below Examination findings may vary depending on the part of the body affected by the necrotizing vasculitis. Neurologic examination may show single or multiple neuropathy (nerve damage). A biopsy of the suspected muscle, nerve biopsy, or organ or tissue biopsy shows vasculitis. A chest x-ray indicates lesions of the chest. A sedimentation rate that is elevated (nonspecific finding). A urinalysis shows blood, casts, urine protein, or other abnormalities. Hepatitis blood tests are positive. Blood test for antibodies against neutrophils (ANCA antibodies); these antibodies are often seen in vasculitic disorders.

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