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Hemolytic-uremic syndrome (HUS)

Alternative Names: HUS Symptoms: Early symptoms: Fever Vomiting and diarrhea Blood in the stools Irritability Weakness Lethargy Later developing symptoms: Low urine output No urine output Paleness Bruising Skin rash that looks like fine red spots (petechiae) Yellowish coloration to the skin (jaundice) Decreased consciousness Seizures -- rare Text Continues Below Signs and tests: A physical examination may show an enlarged liver or spleen. There may be variable, abnormal nervous system changes. There is laboratory evidence of hemolytic anemia and acute renal failure. A complete blood count (CBC ) might show: Decreased platelet count (thrombocytopenia) Rupture of red blood cells Anemia from loss of red blood cells (hemolytic anemia) Elevated white blood count Coagulation studies such as PT and PTT may be normal or abnormal. Blood chemistry such as a chem-20 shows abnormalities, such as: BUN is elevated Creatinine is elevated Free hemoglobin is elevated A urinalysis demonstrates: Blood in the urine Protein in the urine A urine protein test can be used to show the amount of protein in the urine. Other tests: Stool culture may be positive for a specific type of E. coli. Kidney biopsy shows diagnostic changes.

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