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Von Willebrand disease

Symptoms: Nose bleeds Bleeding of the gums Abnormal menstrual bleeding Bruising Skin rash Signs and tests: Normal platelet count Prolonged bleeding time Reduced von Willebrand factor level Reduced platelet aggregation (platelet aggregation test) Ristocetin co-factor is reduced This disease may also alter the results of the following tests: Factor VIII level Von Willebrand factor multimers References: Kumar V, Abbas AK, Fausto N. Robbins and Cotran Pathologic Basis of Disease. 7th ed. St. Louis, Mo: WB Saunders; 2005:654-655. Text Continues Below Noble J. Textbook of Primary Care Medicine. 3rd ed. St. Louis, Mo: Mosby; 2001:1047. Marx J. Rosen’s Emergency Medicine: Concepts and Clinical Practice. 5th ed. St. Louis, Mo: Mosby; 2002:1693.

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