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Medications such as desamino-8-arginine vasopressin (DDAVP) can be given to raise the levels of von Willebrand factor, which will reduce the tendency toward bleeding.
Blood plasma or certain factor VIII preparations may also be used to decrease bleeding.
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Some types of von Willebrand disease do not respond to DDAVP. Tests should be done to determine a patient's specific type of von Willebrand disease, before trauma or surgery occurs. A trial of DDAVP can be done prior to surgery to test whether von Willebrand factor levels increase.
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