Factor V deficiency

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Blood clot formation

Blood clots

Factor V deficiency is an inherited condition that affects the ability of the blood to clot.

Parahemophilia; Owren's disease

Normal blood coagulation is a complex process involving as many as 20 different proteins in blood plasma, which are known as blood coagulation factors. A series of complex chemical reactions using these factors takes place very rapidly to form a protein called fibrin, which stops bleeding.

Factor V deficiency is caused by a lack of the plasma protein Factor V. When certain coagulation factors are low or missing, the chain reaction does not take place normally. Factor V deficiency is rare, and can be caused by inheriting a defective Factor V gene or by acquiring an antibody that interferes with normal Factor V function.

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You can acquire an inhibitor of Factor V:

• After giving birth
• After being treated with a certain type of fibrin glue
• After surgery
• With autoimmune diseases and certain cancers

Sometimes the cause is unknown.

The disease is similar to hemophilia, except bleeding into joints is less common. In the inherited form of Factor V deficiency, a family history of a bleeding disorder is a risk factor.

Excessive bleeding with menstrual periods and after delivery often occurs. Men and women are affected equally. About 1 person per 1 million has the disorder.

Review Date: 03/28/2010
Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; James R. Mason, MD, Oncologist, Director, Blood and Marrow Transplantation Program and Stem Cell Processing Lab, Scripps Clinic, Torrey Pines, California. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission (www.urac.org).