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Waldenstroms Antibodies
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Macroglobulinemia of Waldenstrom
Alternative Names: Waldenstrom's macroglobulinemia; Macroglobulinemia - primary Symptoms: Fatigue Easy bruising of the skin Rash Nosebleeds (epistaxis) Bleeding of the gums Unintentional weight loss Vision loss in one eye Headache Dizziness Blurred or decreased vision Mental status changes Peripheral neuropathy (changes in the nerves affecting the hands, feet, fingers, toes, ears, or nose) manifested by: Numbness or tingling Burning pain Additional symptoms that may be associated with this disease: Swollen glands Flank pain Bluish skin discoloration Fingers that change color upon pressure Signs and tests: Text Continues Below A physical examination may reveal enlarged spleen, liver, and lymph nodes. A retinal eye examination (examination of the eye with an ophthalmoscope) may reveal enlarged (engorged) retinal veins or retinal bleeding (hemorrhages). A CBC shows low red blood cell count and platelet count. Serum protein electrophoresis shows a monoclonal spike (increased amount of a monoclonal protein). This may be seen as a serum immunoelectrophoresis that shows an IgM spike or a serum immunofixation that shows an IgM spike. Urine immunoelectrophoresis shows IgM or a urine test for urine Bence-Jones proteins (quantitative) may be positive. Bone lesions are very rare. If they are present, a bone marrow examination will show cells that resemble both lymphocytes and plasma cells. A blood chemistry shows evidence of renal disease (kidney disease). Page:  1 | 2 | Next >>