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Central nervous system
Central nervous system


Pick’s disease

Alternative Names:
Primary progressive aphasia, Aphasia -- primary progressive; Semantic dementia, Dementia - semantic; Frontotemporal dementia; Arnold Pick's disease

Symptoms:

Behavior changes

  • Inappropriate behavior
  • Compulsive behaviors (for example, overeating or only eating one type of food)
  • Repetitive behavior
  • Withdrawal from social interaction
  • Inability to function or interact in social or personal situations
  • Can't keep a job
  • Problems with personal hygiene
Text Continues Below



Emotional changes

  • Abrupt mood changes
  • Does not show emotional warmth, concern, empathy, sympathy
  • Indifference to events or environment (apathy)
  • Does not recognize behavioral changes
  • Inappropriate mood
  • Decreased interest in daily living activities

Language changes

  • Echolalia (person repeats anything spoken to them)
  • Aphasia (decreased language ability, difficulty speaking or understanding speech)
  • Difficulty finding a word
  • Shrinking vocabulary
  • Weak, uncoordinated speech sounds
  • Can't speak (mutism)
  • Decreased ability to read or write

Neurological problems

  • Weakness
  • Increased muscle tone (rigidity)
  • Movement/coordination difficulties (apraxia)
  • Memory loss that gets worse

Other problems



Signs and tests:

The doctor will ask you about your medical history and symptoms.

Tests may be ordered to help rule out other causes of dementia, including dementia due to metabolic causes. A neurological examination can help reveal what part of the brain is affected. Psychological studies and tests of sensation, cognitive function, and motor function may be abnormal.

  • Neuropsychological assessment shows a pattern of mental decline that suggests selective loss of cognitive function that can be localized to the frontal and/or temporal lobes of the brain.
  • An EEG (electroencephalogram) shows nonspecific changes in electrical activity of the brain.
  • A head CT scan shows loss of tissue mass of affected lobes of the brain.
  • A brain MRI can detect mild degrees of frontal and temporal atrophy missed by the head CT scan.
  • Cerebrospinal fluid examination after a lumbar puncture is usually normal.

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