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Wilson's disease
Alternative Names: Hepatolenticular degeneration Symptoms: enlargement of the abdomen (abdominal distention) splenomegaly yellow skin (jaundice) or eye color (icterus) vomiting blood weakness tremors of the arms or hands difficulty moving extremities, stiffness abnormal extremity posture (dystonia) slow movements difficulty walking movement - unpredictable and jerky movement - uncontrollable movement - slow weakness of the head, neck, face, or arms speech impairment, poor enunciation slow or decreased facial movement/expression emotional or behavioral changes confusion or delirium dementia (loss of multiple brain functions) Signs and tests: An eye examination may show: Kayser-Fleischer rings (rusty or brown-colored ring around the iris). Eye movement may be restricted. Text Continues Below A physical examination may show signs of: Liver or spleen disorders (including cirrhosis and liver necrosis) Damage to the central nervous system including loss of coordination, loss of muscle control, muscle tremors, loss of cognitive and intellectual functions, loss of memory, confusion (delirium or dementia), and other damage. Lab findings may include: Serum ceruloplasmin - low (although it is normal in 5% of cases) Serum copper - low in spite of the copper deposits in tissues Urine copper - high CBC - may show hemolytic anemia or decreased white blood cell count Serum uric acid levels - low Page:  1 | 2 | Next >>