Erythema multiforme

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Erythema multiforme, circular lesions - hands	Erythema multiforme, target lesions on the palm	Erythema multiforme on the hand	Erythema multiforme on the hands
Erythema multiforme on the leg	Exfoliation following erythroderma

Erythema multiforme is a skin disorder due to an allergic reaction or infection.

Lyell's syndrome; Stevens-Johnson syndrome; Erythema multiforme minor; Erythema multiforme major

Erythema multiforme is a type of hypsersensitivity reaction that occurs in response to medications, infections, or illness. Medications include:

• Barbiturates
• Penicillins
• Phenytoin
• Sulfonamides

Infections include:

• Herpes simplex
• Mycoplasma

The exact cause is unknown. The disorder is believed to involve damage to the blood vessels of the skin, followed by damage to skin tissues.

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Some forms of this condition are more severe than others.

• Erythema multiforme minor is not very serious. Most erythema multiforme is caused by herpes simplex or mycoplasma infections.
• Erythema multiforme major is more severe, and is known as Stevens-Johnson syndrome. The more severe form is usually caused by reactions to medications, rather than infections.

Erythema multiforme occurs primarily in children and young adults.

Review Date: 10/10/2010
Reviewed By: Linda J. Vorvick, MD, Medical Director, MEDEX Northwest Division of Physician Assistant Studies, University of Washington School of Medicine. Also reviewed by Kevin Berman, MD, PhD, Atlanta Center for Dermatologic Disease, Atlanta, GA. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission (www.urac.org).