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Once infected, the virus stays in the body for the rest of the individual's life. Some never have another episode, and some have frequent recurrences. In most recurrences, no obvious trigger is identified. Many people, however, find that attacks of genital herpes occur in conjunction with the following conditions:
- general illness (from mild illnesses to serious conditions, such as operations, heart attacks, pneumonia and so on)
- fatigue
- physical or emotional stress
- immunosuppression, due to AIDS or such medication as chemotherapy or steroids
- trauma to the affected area, including sexual activity
- menstruation
In individuals with normal immune systems, genital herpes remains a localized and bothersome infection, but seldom a life-threatening infection.
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