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Crigler-Najjar syndrome

Alternative Names: Glucuronyl transferase deficiency (type I Crigler-Najjar); Arias syndrome (type II Crigler-Najjar) Treatment: Phototherapy is needed on an ongoing basis throughout life. In infants this is done using bilirubin lights (bili or 'blue' lights). Phototherapy becomes less successful after 4 years because thickened skin blocks the light. Text Continues Below Liver transplantation has been used successfully for some people with type I disease. Expectations (prognosis): Affected individuals who reach adulthood will develop kernicterus despite ongoing treatment. The life expectancy for type I disease has been extended from death in childhood to people now living to at least age 30. Complications: Possible complications include: Kernicterus Chronic yellow skin/eyes Calling your health care provider: Seek genetic counseling if you are planning a pregnancy and have a family history of Crigler-Najjar. Call your health care provider if you or your newborn infant has prolonged jaundice.

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