Lack of intrinsic factor

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Megaloblastic anemia - view of red blood cells

Intrinsic factor is a natural substance normally found in the stomach. You need this substance to absorb vitamin B12 from foods.

A lack of intrinsic factor leads to pernicious anemia and vitamin B12 deficiency, which can cause anemia and brain and nervous system (neurological) problems.

Intrinsic factor - lack of

Babies that are born without intrinsic factor cannot properly absorb vitamin B12 starting around age 6 months. Children who have the juvenile type of lack of intrinsic factor tend to show signs and symptoms after age 10.

Older adults get pernicious anemia, which is caused by a lack of intrinsic factor production. This is usually due to an autoimmune disease that causes the stomach lining to waste away (atrophy). The stomach lining is where intrinsic factor is usually made.

Review Date: 01/31/2010
Reviewed By: Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission (www.urac.org).

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