Metabolic neuropathies

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Central nervous system

Metabolic neuropathies are nerve disorders that occur with diseases that disrupt the chemical processes in the body.

See also: Alcoholic neuropathy; Diabetic neuropathy

In some cases, nerve damage is caused by the inability to properly use energy in the body -- often due to a nutritional deficiency. In other cases, dangerous substances (toxins) build up in the body and damage nerves.

Diabetes is one of the most common causes of metabolic neuropathies. People who are at the highest risk of nerve damage from diabetes include:

• Those with damage to the kidneys or eyes
• Those with poorly controlled blood sugar

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Other common metabolic causes of neuropathies include:

• Alcoholism
• Low blood sugar (hypoglycemia)
• Kidney failure
• Porphyria
• Severe infection throughout the body (sepsis)
• Thyroid disease
• Vitamin deficiencies (including vitamins B-12, E, and B-1)

Some metabolic disorders are passed down through families (inherited), while others develop due to various diseases.

Review Date: 02/06/2010
Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; Luc Jasmin, MD, PhD, Department of Neurosurgery at Cedars-Sinai Medical Center, Los Angeles, CA, and Department of Anatomy at UCSF, San Francisco, CA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission (www.urac.org).