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Morquio syndrome

Alternative Names: Mucopolysaccharidosis type IVA (galactosamine-6-sulfatase deficiency); Mucopolysaccharidosis type IVB (beta galactosidase deficiency) Treatment: There is no specific treatment for Morquio syndrome. Symptoms are treated as they occur. Patients with Morquio syndrome should have MRI of the lower skull and upper neck to determine if the upper vertebrae are underdeveloped. If they are, a spinal fusion may prevent irreversible spinal cord injury. Text Continues Below Bone marrow transplantation or enzyme replacement therapy may be available in the future. Support Groups: National MPS Society --www.mpssociety.org Expectations (prognosis): Bone abnormalities represent a significant problem, and correction through surgery should be made where possible. For example, small vertebrae at the top of the neck can cause slippage that damages the spinal cord so that paralysis may result. Death may occur as a result of cardiac complications. Complications: Heart failure Difficulty with vision Walking problems related to abnormal curvature of the spine Abnormal neck bones can cause spinal cord damage that can cause severe disease including paralysis if not caught early -- spinal fusion can prevent this Breathing problems Calling your health care provider: Call your health care provider if symptoms of Morquio syndrome occur.

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