Medical Health Encyclopedia

Injury Disease Nutrition Poison Symptoms Surgery Test Special Topic

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Anterior skeletal anatomy

Overview Symptoms Treatment Prevention

McCune-Albright syndrome

Alternative Names: Polyostotic fibrous dysplasia Symptoms: Irregular, patchy cafe-au-lait spots, especially on the back Vaginal bleeding (first menstruation) at a very early age Premature puberty early breast development early pubic and armpit hair development Some patients get more broken bones Rarely, a form of gigantism (overgrowth of the body caused by excess hormones) Signs and tests: A physical examination may show signs of: Hyperthyroidism (occasionally) Adrenal abnormalities (occasionally) Acromegaly (occasionally) Cafe-au-lait spots of the skin Text Continues Below Tests may show signs of hyperthyroidism, hyperparathyroidism, excess adrenal hormones, or excess blood prolactin or growth hormone. X-rays show fibrous dysplasia that affects multiple bones. An MRI of the head may show a type of tumor called an adenoma in the pituitary gland. Genetic testing may be available for the GNAS1 gene.

A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission (www.urac.org). The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. Copyright 2004 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.