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Anterior skeletal anatomy
Anterior skeletal anatomy


McCune-Albright syndrome

Alternative Names:
Polyostotic fibrous dysplasia

Symptoms:
  • Irregular, patchy cafe-au-lait spots, especially on the back
  • Vaginal bleeding (first menstruation) at a very early age
  • Premature puberty
    • early breast development
    • early pubic and armpit hair development
  • Some patients get more broken bones
  • Rarely, a form of gigantism (overgrowth of the body caused by excess hormones)


Signs and tests:

A physical examination may show signs of:

  • Hyperthyroidism (occasionally)
  • Adrenal abnormalities (occasionally)
  • Acromegaly (occasionally)
  • Cafe-au-lait spots of the skin
Text Continues Below



Tests may show signs of hyperthyroidism, hyperparathyroidism, excess adrenal hormones, or excess blood prolactin or growth hormone.

X-rays show fibrous dysplasia that affects multiple bones. An MRI of the head may show a type of tumor called an adenoma in the pituitary gland. Genetic testing may be available for the GNAS1 gene.




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