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McCune-Albright syndrome

Alternative Names: Polyostotic fibrous dysplasia Treatment: There is not a specific treatment for McCune-Albright syndrome. Drugs that inhibit estrogen production, such as testolactone, have been tried with some success. Text Continues Below Adrenal abnormalities (such as Cushing's syndrome) may be treated by surgery to remove the adrenal glands. Gigantism and pituitary adenoma will require treatment with hormone inhibitors or surgery. Expectations (prognosis): Life span is relatively normal. Complications: Repeated episodes of broken bones Cosmetic problems resulting from bone abnormalities Blindness Deafness Tumors Premature puberty Osteitis fibrosa cystica Calling your health care provider: Call your health care provider if your child develops evidence of premature puberty (before the expected age) or has other symptoms suggestive of McCune-Albright syndrome. Genetic counseling, and possibly genetic testing, may be recommended if the disease is diagnosed.

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