McCune-Albright syndrome

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Anterior skeletal anatomy

Polyostotic fibrous dysplasia

There is no specific treatment for McCune-Albright syndrome. Drugs that block estrogen production, such as testolactone, have been tried with some success.

Adrenal abnormalities (such as Cushing syndrome) may be treated with surgery to remove the adrenal glands. Gigantism and pituitary adenoma will need treatment with hormone inhibitors or surgery.

Lifespan is relatively normal.

• Blindness
• Cosmetic problems from bone abnormalities
• Deafness
• Osteitis fibrosa cystica
• Premature puberty
• Repeated broken bones
• Tumors of the bone (rare)

Call your health care provider if your child starts puberty early, or has other symptoms of McCune-Albright syndrome. Genetic counseling, and possibly genetic testing, may be recommended if the disease is diagnosed.

Review Date: 09/10/2010
Reviewed By: Chad Haldeman-Englert MD, Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission (www.urac.org).

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