Medical Health Encyclopedia

Chronic granulomatous disease


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Alternative Names

CGD; Fatal granulomatosis of childhood; Chronic granulomatous disease of childhood; Progressive septic granulomatosis


Symptoms
  • Swollen lymph nodes in the neck; those develop early in life, and stay swollen or occur frequently
  • Abscess formation in the lymph nodes of the neck -- requires surgical drainage
  • Frequent and difficult-to-clear skin infections
    • Chronic infection inside the nose
    • Impetigo
    • Abscesses
    • Furuncles
    • Impetiginized eczema (eczema complicated by an infection)
    • Perianal abscesses (abscesses around the anus)
  • Pneumonia
    • Occurs frequently
    • Difficult to clear
  • Persistent diarrhea
  • Bone infections
  • Joint infections




Signs and tests

Physical examination may show an enlarged liver ( hepatomegaly ), enlarged spleen (splenomegaly), and swelling of multiple lymph nodes all over the body (generalized adenopathy). Signs of osteomyelitis may appear, sometimes affecting multiple bones.

A tissue biopsy may show granulomas (groups of abnormal phagocytes).

Other tests may include:



Review Date: 09/05/2006
Reviewed By: D. Scott Smith, M.D., MSc, DTM&H, Chief of Infectious Disease & Geographic Medicine, Kaiser Redwood City, CA & Adjunct Assistant Professor, Stanford University. Review provided by VeriMed Healthcare Network.

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