Chronic granulomatous disease

A
• B
• C
• D
• E
• F
• G
• H
• I
• J
• K
• L
• M
• N
• O
• P
• Q
• R
• S
• T
• U
• V
• W
• X
• Y
• Z

Antibodies

CGD; Fatal granulomatosis of childhood; Chronic granulomatous disease of childhood; Progressive septic granulomatosis

• Swollen lymph nodes in the neck; those develop early in life, and stay swollen or occur frequently
• Abscess formation in the lymph nodes of the neck -- requires surgical drainage
• Frequent and difficult-to-clear skin infections
  • Chronic infection inside the nose
  • Impetigo
  • Abscesses
  • Furuncles
  • Impetiginized eczema (eczema complicated by an infection)
  • Perianal abscesses (abscesses around the anus)
• Pneumonia
  • Occurs frequently
  • Difficult to clear
• Persistent diarrhea
• Bone infections
• Joint infections

---

---

Physical examination may show an enlarged liver ( hepatomegaly ), enlarged spleen (splenomegaly), and swelling of multiple lymph nodes all over the body (generalized adenopathy). Signs of osteomyelitis may appear, sometimes affecting multiple bones.

A tissue biopsy may show granulomas (groups of abnormal phagocytes).

Other tests may include:

• Nitroblue tetrazolium test (NBT) to confirm the disease and detect carrier state in the mother
• Chemiluminescence assay to confirm the disease
• CBC
• ESR
• Chest X-ray
• Bone scan
• Liver scan

Review Date: 09/05/2006
Reviewed By: D. Scott Smith, M.D., MSc, DTM&H, Chief of Infectious Disease & Geographic Medicine, Kaiser Redwood City, CA & Adjunct Assistant Professor, Stanford University. Review provided by VeriMed Healthcare Network.