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Chronic granulomatous disease

Alternative Names: CGD Symptoms: swollen lymph nodes in the neck that develop early in life and that persist or occur frequently abscess formation in the lymph nodes of the neck that requires surgical drainage frequent and difficult-to-clear skin infections chronic infection inside the nose impetigo abscesses furuncles impetiginized eczema (eczema complicated with an infection) perianal abscess pneumonia occurs frequently is difficult to clear persistent diarrhea bone infections joint infections Signs and tests: Physical examination may show an enlarged liver (hepatomegaly), enlarged spleen (splenomegaly) and swelling of multiple lymph nodes all over the body (generalized adenopathy). Signs of osteomyelitis may appear, sometimes affecting multiple bones. Text Continues Below Tissue samples may be obtained for biopsy, which may show granulomas. Other tests may include: nitroblue tetrazolium test (NBT) to confirm the disease and detect carrier state in the mother chemiluminescence assay to confirm the disease CBC ESR chest X-ray bone scan liver scan

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