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Medical Health Encyclopedia
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Chronic fatigue syndrome

Alternative Names:
CFS; Fatigue - chronic

Symptoms:

Symptoms of CFS are similar to those of most common viral infections (muscle aches, headache, and fatigue), often developing within a few hours or days and lasting for 6 months or more.

Text Continues Below



Main symptoms:

  • Fatigue or tiredness, never experienced to this extent before (new onset), lasting at least 6 months and not relieved by bed rest
  • Fatigue that is severe enough to restrict activity (serious fatigue develops with less than one-half of the exertion compared to before the illness)

Other symptoms:

  • Fatigue lasting more than 24 hours after an amount of exercise that would normally be easily tolerated
  • Mild fever (101 degrees F or less)
  • Sore throat
  • Lymph node tenderness in the neck or armpit
  • Muscle weakness, all over or multiple locations, not explained by any known disorder
  • Muscle aches (myalgias)
  • Feeling unrefreshed after sleeping an adequate amount of time
  • Headaches, different from previous headaches in quality, severity, or pattern
  • Joint pain, often moving from joint to joint (migratory arthralgias), without joint swelling or redness
  • Forgetfulness or other similar symptoms including difficulty concentrating, confusion, or irritability


Signs and tests:

Physical examination may confirm the fever, lymph node tenderness, lymph node swelling, or other symptoms. The throat may appear red without drainage or pus.

The health care provider can presume a diagnosis of chronic fatigue syndrome (CFS) only after ruling out all other known possible causes of fatigue, such as:

  • Infections
  • Immune or autoimmune disorders
  • Tumors.
  • Muscle or nerve diseases (such as multiple sclerosis)
  • Endocrine diseases (such as hypothyroidism)
  • Psychiatric or psychological illnesses, particularly depression (since CFS itself may be associated with depression, a diagnosis of depression does not rule out CFS but fatigue related to depression alone must be ruled out for CFS to be diagnosed)
  • Drug dependence
  • Other illnesses (such as heart, kidney, liver diseases)

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