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Hyperimmunoglobulin E syndrome

Alternative Names: Job syndrome; Hyper IgE syndrome Symptoms: Persistent skin abscesses and infection Recurrent pus in the sinus Eczema Bone and tooth defects, including fractures and late shedding of baby teeth Signs and tests: Keratoconjunctivitis Osteomyelitis Kyphoscoliosis Lung abscesses on chest x-ray Recurrent sinus infection Tests to confirm a diagnosis: Quantitative immunoglobulins reveal high blood IgE levels Marked eosinophilia  (large amount of white blood cells) by CBC with differential Defective neutrophil and monocyte chemotactic studies (though not in all cases) Absent delayed hypersensitivity (DCNB, candidal) Text Continues Below Other tests may be done in response to infections: X-ray of the sinuses X-ray of the bones X-ray and CT scan of the chest Cultures of infected site

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