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Congenital afibrinogenemia

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Congenital afibrinogenemia

Definition:

Congenital afibrinogenemia is a rare, inherited blood disorder in which the blood does not clot normally due to a lack of or a malfunction involving fibrinogen, a protein necessary for coagulation.

Causes, incidence, and risk factors:

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This rare disease is caused by an autosomal recessive gene, which requires inheritance of the abnormal gene from both parents. There may be either a complete lack of fibrinogen or a defect in the functioning of available fibrinogen. This condition can occur in both sexes. The main risk factor is a family history of bleeding disorders.

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