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The goal of treatment is to control symptomatic infection. A fungus ball usually does not require treatment unless bleeding into the lung tissue is associated with the infection, then surgical removal is required.
Invasive aspergillosis is treated with several weeks of intravenous amphotericin B, an antifungal medication. Itraconazole or voriconazole can also be used.
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Endocarditis caused by Aspergillus is treated by surgical removal of the infected heart valves and long-term amphotericin B therapy.
Allergic aspergillosis is treated with oral prednisone. Some people may benefit from allergy desensitization. Antifungal agents do not help people with allergic aspergillosis.
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