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Pectus excavatum
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Osteogenesis imperfecta
Alternative Names: Brittle bone disease Treatment: Fractures must be repaired quickly in the usual ways to avoid deformities. There is no specific treatment for the underlying disease. However, there are several therapies that may improve the quality of life for patients with OI: Good nutrition and directed exercise is key in helping to optimize bone and muscle strength. Physical rehabilitation and therapy can be quite beneficial. Swimming is an excellent conditioning exercise for many people with OI. Surgical procedures, including the placement of metal rods through bones, can help strengthen bones and prevent deformity. Braces and walking aids are helpful for some. The use of biphosphonates in children with OI is currently being researched with some promising results. Other medical interventions -- including bone marrow transplant, the use of growth hormone, and gene therapy -- are also under investigation. Expectations (prognosis): Text Continues Below Permanent deformity of the extremities may occur. Brain damage may result from skull fractures. The disorder can be fatal. The disease is grouped by type: Type 1 - Mild -- Compatible with normal life expectancy. Type 2 - Lethal -- Most, but not all, die in early childhood. Type 3 - Progressive deforming -- Decreased life expectancy. Type 4 - Moderately severe -- Compatible with normal life expectancy. Complications: Recurrent pneumonia Heart failure (cor pulmonale) Brain damage Permanent deformity Breathing problems Hearing loss Calling your health care provider: Page:  1 | 2 | Next >>