Canavan disease

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Canavan disease is an inherited condition that affects the breakdown and use (metabolism) of aspartic acid.

Spongy degeneration of the brain; Aspartoacylase deficiency

Canavan disease is passed down (inherited) through families. It is more common among Ashkenazi Jews than in the general population.

The lack of the enzyme, aspartoacylase, leads to a buildup of material called N-acetylaspartic acid in the brain. This causes the white matter of the brain to break down (deteriorate).

Review Date: 11/10/2010
Reviewed By: A.D.A.M. Editorial: David Zieve, MD, MHA, and David R. Eltz. Previously reviewed by Luc Jasmin, MD, PhD, Departments of Anatomy and Neurological Surgery, University of California, San Francisco, CA. Review provided by VeriMed Healthcare Network (10/14/2009).

A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission (www.urac.org).

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