Medical Health Encyclopedia

Drug abuse

PCP may be administered in different ways. The onset of effects is related to the means of administration. If dissolved, PCP may be taken intravenously ("shot up") and its effects noted within seconds.

Sprinkled over dried parsley, oregano, or marijuana leaves, it can be smoked and effects noted within 2-5 minutes, peaking at 15-30 minutes. Taken orally, in pill form or mixed with food or beverages, PCP's effects are usually noted within 30 minutes and tend to peak at about 2-5 hours.

Lower doses of PCP typically produce euphoria (feelings of joy) and decreased inhibition similar to drunkenness. Mid-range doses cause numbness throughout the body with changes in perception that may result in extreme anxiety and violence.

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Large doses may produce paranoia, auditory hallucinations, psychosis similar to schizophrenia. Massive doses, more commonly associated with ingesting the drug, may cause cardiac arrhythmias, seizures, muscle rigidity, acute kidney failure, and death. Because of the analgesic (pain-killing) properties of PCP, users who incur significant injuries may not feel any pain.

Ketamine, a compound related to PCP, has grown in popularity in recent years. It is commonly referred to as Special K.

HALLUCINOGENS

In addition to PCP, other commonly abused hallucinogens include LSD (lysergic acid diethylamide), psilocybin (mushrooms, "shrooms"), and peyote (a cactus plant containing the active ingredient mescaline).

The use of naturally occurring hallucinogens, specifically for religious rites, has been documented for centuries. Mushrooms containing psilocybin were used by the native people of Mexico and peyote use was common among southwestern Native Americans.

In contrast, LSD is a synthetic substance, first developed by a legitimate pharmaceutical company in 1938. Today, most hallucinogens are used experimentally rather than on a regular basis, with most users reporting only single or several uses per year.