Because the antigen is obtained from sterile pus derived from human lymph nodes, there is a small potential risk of transmission of viruses. Also, there are occasional local reactions that may occur, such as itching and (rarely) hives.
Although this test has historical value -- it was used in the past as one of the keys to diagnosis -- there are better tests available for the diagnosis of CSD. In addition, the CSD antigen has not been standardized, is not widely available, and carries the potential risk of transmitting other pathogens such as viruses.
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