Ketones - urine

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Male urinary system

A ketones urine test measures the presence or absence of ketones in the urine.

Ketone bodies - urine; Urine ketones

The test requires a clean catch urine sample.

To obtain a clean catch sample, men or boys should clean the head of the penis. Women or girls need to wash the area between the lips of the vagina with soapy water and rinse well.

As you start to urinate, allow a small amount to fall into the toilet bowl to clear the urethra of contaminants. Then, put a clean container under your urine stream and catch 1 to 2 ounces of urine. Remove the container from the urine stream. Cap and mark the container and give it to the health care provider or assistant.

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For infants, thoroughly wash the area around the urethra. Open a urine collection bag (a plastic bag with an adhesive paper on one end), and place it on the infant. For boys, the entire penis can be placed in the bag and the adhesive attached to the skin. For girls, the bag is placed over the labia. Diaper as usual over the secured bag.

This procedure may take a couple of attempts -- lively infants can displace the bag. The infant should be checked frequently and the bag changed after the infant has urinated into the bag. The urine is drained into the container for transport to the laboratory.

Urine ketones are usually measured as a "spot test" using a dipstick coated with chemicals that react with ketone bodies. The dipstick is dipped in the urine sample, and a color change indicates the presence of ketones.

You may have to eat a special diet, and you should stop taking any drugs that may affect the test.

If the collection is being taken from an infant, you may need extra collection bags.

The test involves only normal urination, and there is no discomfort.

Ketones are the end-product of rapid or excessive fatty-acid breakdown. Examples of ketones are:

• Acetoacetic acid
• Acetone
• Beta-hydroxybutyric acid

Ketones will be present in the urine when the ketones in the blood go above a certain level.

A number of hormones, including glucagon, epinephrine, and growth hormone can cause fatty acids to be released from body fat (adipose tissue) into the blood. The levels of these hormones increase in starvation, uncontrolled diabetes, and a number of other conditions.

An insulin deficiency relative to the level of glucagon is also present in persons with diabetes.

Review Date: 11/30/2009
Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; Herbert Y. Lin, MD, PHD, Nephrologist, Massachusetts General Hospital; Associate Professor of Medicine, Harvard Medical School. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission (www.urac.org).