CSF-VDRL test

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CSF test for syphilis

The CSF-VDRL test is used to diagnose neurosyphilis. This test looks for antibodies called reagins, which are sometimes produced by the body in reaction to the syphilis-causing bacteria.

See also: VDRL

Venereal disease research laboratory slide test - CSF

The test is performed on a CSF sample obtained by lumbar puncture (spinal tap).

Before the procedure, you will be asked to review the risks and sign a consent form.

Usually, discomfort associated with the lumbar puncture is mild to moderate. The entire procedure usually takes about 30 minutes but may take longer. The actual fluid collection only takes a few minutes.

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The CSF-VDRL test is used to diagnose syphilis in the brain or spinal cord. Brain and spinal cord involvement usually indicates late stage (tertiary) syphilis.

Blood screening tests, such as VDRL and RPR, are more effective during middle stage (secondary) syphilis.

Review Date: 07/27/2009
Reviewed By: Linda J. Vorvick, MD, Medical Director, MEDEX Northwest Division of Physician Assistant Studies, University of Washington, School of Medicine; and Susan Storck, MD, FACOG, Chief, Eastside Department of Obstetrics and Gynecology, Group Health Cooperative of Puget Sound, Redmond, Washington; Clinical Teaching Faculty, Department of Obstetrics and Gynecology, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission (www.urac.org).