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LH response to GnRH

Alternative Names: Luteinizing hormone response to gonadotropin-releasing hormone Normal Values: Normal LH levels are: Children: < 2.0 IU/ml Male: 0.9 to 10.6 IU/ml Female; follicular: 1.1 to 11.1 IU/ml Female; mid-cycle: 17.5 to 72.9 IU/ml Female; luteal; 0.4 to 15.1 IU/ml Female; post menopausal: 6.8 to 46.6 IU/ml Text Continues Below Note: IU/ml = international units per milliliter. What abnormal results mean: An excess LH response suggests primary gonadal failure (the problem is within the ovaries or testes). A reduced LH response suggests hypothalamic or pituitary disease. A gonadotropin deficiency can be present at birth as a congenital or hereditary disorder. Kallmann's syndrome is a rare congenital disease characterized by gonadotropin deficiency caused by GnRH deficiency. Acquired defects of GnRH production are more common (hyperprolactinemia or amenorrhea may be caused by inhibition of GnRH release, possibly due to increased hypothalamic dopamine or prolactin). Anorexia nervosa and starvation inhibit GnRH release. A gonadotropin deficiency may be a relatively early problem in patients with large pituitary adenomas (tumors). A gonadotropin deficiency also occurs in patients with polyglandular endocrine deficiency (an autoimmune disorders ) and in people with hemochromatosis.

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