Drugs that may cause impotence

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Among the antihypertensive medications, thiazides are the most common cause of ED, followed by beta-blockers. Alpha-blockers are, in general, less likely to cause this problem.

Parkinson's disease medications:

• Benztropine (Cogentin)
• Biperiden (Akineton)
• Bromocriptine (Parlodel)
• Levodopa (Sinemet)
• Procyclidine (Kemadrin)
• Trihexyphenidyl (Artane)

Chemotherapy and hormonal medications:

• Antiandrogens (Casodex, Flutamide, Nilutamide)
• Busulfan (Myleran)
• Cyclophosphamide (Cytoxan)
• Ketoconazole
• LHRH agonists (Lupron, Zoladex)

Other medications:

• Aminocaproic acid (Amicar)
• Atropine
• Clofibrate (Atromid-S)
• Cyclobenzaprine (Flexeril)
• Cyproterone
• Digoxin (Lanoxin)
• Disopyramide (Norpace)
• Estrogen
• Finasteride (Propecia, Proscar, Avodart)
• Furazolidone (Furoxone)
• H2 blockers (Tagamet, Zantac, Pepcid)
• Indomethacin (Indocin)
• Lipid-lowering agents
• Licorice
• Metoclopramide (Reglan)
• NSAIDs (Ibuprofen, etc.)
• Orphenadrine (Norflex)
• Prochlorperazine (Compazine)
• Pseudoephedrine (Sudafed)

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Opiate analgesics (painkillers)

• Codeine
• Fentanyl (Innovar)
• Hydromorphone (Dilaudid)
• Meperidine (Demerol)
• Methadone
• Morphine
• Oxycodone (Oxycontin, Percodan)

Recreational drugs:

• Alcohol
• Amphetamines
• Barbiturates
• Cocaine
• Marijuana
• Heroin
• Nicotine

Review Date: 10/11/2010
Reviewed By: Louis S. Liou MD, PhD, Chief of Urology, Cambridge Health Alliance, Visiting Assistant Professor of Surgery, Harvard Medical School. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission (www.urac.org).