Medical Health Encyclopedia

One 2002 study, however, reported a significantly higher risk for ulcers (38%) in people who regularly took both Fosamax and naproxen compared to either drug alone. (The risk for ulcers was 8% with Fosamax alone and 12% with naproxen alone.) Naproxen (e.g., Aleve) is one of the NSAIDs, which are common pain relievers used for many conditions. Others include aspirin and ibuprofen (Motrin IB, Advil, Nuprin, Rufen), naproxen, ketoprofen (Actron, Orudis KT). Long-term use of NSAIDs alone is known to increase the risk of ulcers, so both agents may have a double effect on the stomach lining. It is not known yet if the risks for these adverse actions are as high with other combinations. For example, ibuprofen may have a lower risk for ulcers than naproxen, and Actonel may have fewer adverse effects on the stomach than Fosamax. Because so many older people take NSAIDs regularly clarifying these effects is very important.

Other Adverse Effects. Risedronate was associated with higher risk for lung cancer in one study, although not in others. (This association has not been found with other bisphosphonates.) More research needed.

Hormone Replacement Therapy

Based on early studies, many physicians used to believe that HRT might be beneficial for reducing the risk of heart disease and bone fractures caused by osteoporosis (thinning of the bones) in addition to treating menopausal symptoms. The results of a new study, called the Women's Health Initiative (WHI), has led physicians to revise their recommendations regarding HRT.

Text Continues Below

---

The WHI, started in 1993, has enrolled 161,809 women between the ages of 50-79 in 40 different medical centers. Part of the study was intended to examine the health benefits and risks of hormone replacement therapy, including the risks of breast cancer, heart attacks, strokes, and blood clots.