Cervical Cancer - Treatment for CIN and Carcinoma in Situ

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Stage IA1. Treatment options for stage IA1 may include:

• Conization
• Total hysterectomy
• Radical hysterectomy (removal of uterus, cervix, part of vagina, and pelvic lymph nodes)
• Internal radiation therapy

Stage IA2. Treatment options for stage IA2 may include:

• Radical hysterectomy
• External beam radiation therapy plus brachytherapy (implantation of radioactive pellets)
• Radical trachelectomy (removal of the cervix but not the uterus) may be an option for some women who want to preserve fertility

Stage IB1. Treatment options for stage IB1 may include:

• Radical hysterectomy
• High-dose internal and external radiation therapy
• Radical trachelectomy

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Stage IB2. Treatment options for stage 1B2 may include:

• Combination of chemotherapy and radiation therapy
• Radical hysterectomy, followed by radiation therapy (and possibly chemotherapy) if cancer cells are found.

Stage IIA. Treatment options for stage IIA may include:

• Internal and external radiation therapy
• Radiation therapy plus chemotherapy
• Radical hysterectomy followed by radiation therapy and chemotherapy

Stage IIB. Treatment options for stage IIB may include:

• Combined internal and external radiation therapy along with chemotherapy with cisplatin
• Other drugs may be given along with cisplatin

Stage III. Treatment options for stage IIIA and stage IIIB may include:

• Combined internal and external radiation therapy plus chemotherapy Stage IVA.

Treatment options for stage IVA may include:

• Combined internal and external radiation therapy plus chemotherapy

Stage IVB. Stage IVB cancer is generally not considered curable. Treatment options may include:

• Radiation therapy to relieve symptoms and improve quality of life
• Chemotherapy with cisplatin or carboplatin in combination with another drug (paclitaxel, gemcitabine, topotecan, or vinorelbine)

Recurrent Cancer. Cervical cancer may recur locally in the lymph nodes near the cervix, it may spread to distant sites, such as the lung or bones, or it may appear both locally and in distant locations. Treatment options depend on where the cancer has recurred. They include: