Medical Health Encyclopedia

Naltrexone is often prescribed along with psychotherapy. The most common side effect of naltrexone is nausea, which is usually mild and temporary. High doses can cause liver damage. The drug should not be given to anyone who has used narcotics within a week to 10 days. It is important that patients follow their doctors’ orders and take the pill on a daily basis.

Acamprosate. Acamprosate (Campral) is the newest drug to be approved for treatment of alcoholism. Acamprosate calms the brain and reduces cravings by inhibiting the transmission of the neurotransmitter gamma aminobutyric acid (GABA). Studies indicate that it reduces the frequency of drinking and, in concert with psychotherapy, improves quality of life even in patients with severe alcohol dependence. One study reported that 60% of patients remained abstinent for 12 weeks, and in another 43% were still abstinent after nearly a year. The drug may cause occasional diarrhea and headache. It also can impair certain memory functions but does not alter short-term working memory or mood. People with kidney problems should use acamprosate cautiously. For some patients, combination therapy with naltrexone or disulfiram may provide greater benefit than acamprosate alone.

Nalmefene. Nalmefene (Revex) is an injectable opioid antagonist that is similar to naltrexone. It is generally used to reverse the effects of narcotics that are given during surgery. It is being investigated as an anticraving drug for alcohol dependence.

Aversion Medications

Text Continues Below

---

Disulfiram. Some drugs have properties that interact with alcohol to produce distressing side effects. Disulfiram (Antabuse) causes flushing, headache, nausea, and vomiting if a person drinks alcohol while taking the drug. The symptoms can be triggered after drinking half a glass of wine or half a shot of liquor and may last from half an hour to 2 hours, depending on dosage of the drug and the amount of alcohol consumed. One dose of disulfiram is usually effective for 1 to 2 weeks. Overdose can be dangerous, causing low blood pressure, chest pain, shortness of breath, and even death. The drug is more effective if patients have family or social support, including AA "buddies," who are close by and vigilant to ensure that they take it. A 2004 study that compared naltrexone with disulfiram during the course of one year found that 86% of patients treated with disulfiram remained abstinent compared with 44% of patients treated with naltrexone. However, patients treated with naltrexone had lower levels of alcohol craving.

Antidepressants