Medical Health Encyclopedia

PUVA. An alternative phototherapy regimen called PUVA uses oral drugs known as psoralens before UVA treatment. It has been used for other skin diseases, including psoriasis. It may prove to be useful for patients with early-onset diffuse scleroderma. In one study, most of those treated with PUVA for two days a month for up to eight years experienced improvement or stabilization in nearly all scleroderma symptoms. Tests for kidney function remained normal. This treatment is known to increase the risk for skin cancer.

Phototherapy with Psoralen Water Bath. Yet another procedure uses UVA light therapy after patients take a bath containing a solution of the psoralen 8-methoxypsoralen (8-MOP). It is safe and well tolerated although benefits appear to be minor and occur only in a small subset of patients.

Extracorporeal Photopheresis. Another phototherapy treatment under investigation is called extracorporeal photopheresis. It involves withdrawing the patient's blood and treating it with ultraviolet light. Little data exists on its effectiveness and experts do not recommend it at this time. Still, some experts argue that some initial promise in its use warrants more research.

Vitamin D3 Analogs

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A form of vitamin D3, calcipotriene (Dovonex), also called calcipotriol in Europe, appears to help block skin cell proliferation. It also has anti-inflammatory properties and is being investigated as an oral and topical treatment for local scleroderma. It may be prove to be beneficial when combined with low-dose ultraviolet A1 phototherapy.

Immunosuppressive Agents

D-penicillamine is proving to be an effective agent for softening skin and reducing thickness. (Improvements in thickness with this drug have also been associated with improved survival.)

Methotrexate (Rheumatrex) is another agent commonly used may be even more effective than penicillamine.

Oral corticosteroids, such as prednisolone and prednisone, are also often employed.