Although all of these symptoms can be present in other illnesses, they may suggest Hodgkin’s disease particularly when lymph-node swelling lasts more than six weeks and does not respond to antibiotics.
If you have symptoms, your doctor will examine you carefully and check for swelling or lumps in your neck, underarms, or groin. A lymph node biopsy and/or biopsy of the bone marrow is the most reliable way of establishing the diagnosis of Hodgkin’s disease. In order to determine the extent of the Hodgkin’s disease, several scans will be performed, including CT scans, PET scans, and/or Gallium scans. A bone marrow biopsy may also be performed under certain clinical circumstances.
Hodgkin’s disease is staged according to the number of lymph node groups involved.
Stage I - One lymph node group involvedStage II - Multiple lymph nodes either above or below the diaphragm involved
Stage III - Multiple lymph nodes on both sides of the diaphragm involved
Stage IV - Multiple lymph nodes involved with involvement of other organs
Hodgkin’s disease is curable with chemotherapy, radiation therapy, or a combination of both. The likelihood of cure depends on several prognostic factors, include the patient’s age and sex, stage of disease, and results found on blood tests.
Treatment of Hodgkin's Disease
ChemotherapyAlmost all cases of Hodgkin’s disease is treated with combination chemotherapy. The rare exception are some individuals with very favorable prognosis, Stage I disease, where radiotherapy may be used as definitive therapy in certain selected cases.
Chemotherapy for Hodgkin’s disease is considered standard. The most commonly used regimen is called ABVD and is comprised of four chemotherapy agents. These drugs are given intravenously (in the vein) every 14 days, often up to 12 times. Alternate chemotherapy regimens exist, and include the Stanford V regimen, MOPP, and ChlVVP. These alternatives should be discussed with your physician.
Radiation therapy may be given once chemotherapy has been completed if there were large tumor masses or if the masses have not completely disappeared with chemotherapy.
While the goal of initial chemotherapy and/or radiation therapy is to put the Hodgkin’s disease into a long-term remission and cure the disease, Hodgkin’s disease is one of the few cancers that can be successfully treated and cured even if the disease returns. If Hodgkin’s disease returns, it must be treated with chemotherapy again. Once a second remission is attained, a bone marrow transplantation is often used to prevent the disease from returning once again. The likelihood of cure from recurrent Hodgkin’s disease depends largely on the duration of the initial remission as well as the amount of disease that is present at the time of relapse.
Questions To Ask Your Doctor About Hodgkin's Disease
Do the symptoms indicate a diagnosis of Hodgkin's disease?
Are further tests necessary?
What is the staging of the disease?
Has it spread beyond the original site?
What treatment do you recommend?
Will chemotherapy or radiation therapy be needed?
Would bone marrow transplantation help if chemotherapy is needed?
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Editorial review provided by VeriMed Healthcare Network.
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