Patient's Genes May Guide Antidepressant Use

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"This is likely to still be a major finding in [whites] if the replications studies hold up," Carroll said. "If our findings are confirmed and if this genotyping is taken up in clinical services, then the market for SSRI drugs as first-line treatment will fall by around 50 percent. Another implication is that new drug development will shift to dual-action agents."

"The word is now out that depression is a very serious disorder with major public health and economic consequences," he continued. "There is a great deal of motivation on the professional side to do a better job of treating depression and this genetic prediction is an obvious place to start."

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For more on depression, visit the U.S. National Institute of Mental Health (www.nimh.nih.gov ).

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