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FRIDAY, Dec. 8 (HealthDay News) -- New research with rhesus monkeys appears to shed some light on why restricting calories may extend life spans.
Limiting consumption of calories seems to boost key infection-fighting cells in the immune system, the researchers say.
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"The key finding is that in a primate species, which is very similar to ourselves, there is a very remarkable effect on the maintenance of the immune system with caloric restriction," said lead researcher Dr. Janko Nikolich-Zugich, a senior scientist at Oregon Health & Science University's Vaccine and Gene Therapy Institute.
As people age, changes in the immune system dramatically increase susceptibility to infectious diseases. So-called T cells, which make up an important component of the immune response, appear to be the part of the immune system most affected by aging, the researchers said.
In other studies, calorie restriction has been shown to reduce the aging of the immune system in rats. And calorie restriction has also been shown to increase the life span of yeast, worms, flies, zebrafish, and spiders. This same benefit may also hold true for monkeys, the researchers said.
"Under long-term caloric restriction, that was started in young adult monkeys, there is a very remarkable way of preserving both the form and the function of the immune system, which will result in much better resistance to infectious disease," Nikolich-Zugich said.
The study results are published in this week's issue of the Proceedings of the National Academy of Sciences.
In the 42-month study, Nikolich-Zugich and his colleagues found that calorie restriction improved the maintenance and production of T cells in 13 rhesus monkeys, 18 to 23 years of age, whose calories were restricted, compared with 28 monkeys who ate a normal diet.
The researchers found that calorie restriction improved T cell function and reduced the production of inflammatory compounds. These findings suggest that limiting calories can delay immunological aging, and, in turn, life span maybe increased by providing longer-term resistance to infectious diseases.
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