Study Questions 'Off-Label' Use of Antipsychotics

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The study authors called for more head-to-head trials of the drugs.

"The clearest finding was that the quality of evidence for the most common uses was not very clear-cut, which doesn't prove the case that these aren't appropriate to consider in individual patients. But it does say that given the amount of use they're getting, we need some better research to try to clarify how to identify the right patients to get these drugs," Atkins said.

But Corcoran and others called for a different approach.

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"Our sense is not more head-to-head trials but the need to develop other kinds of treatments for disorders other than psychosis, drugs that are safer, more appropriate, using rationale drug design," she said.

More information

View the full report at AHRQ.

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