Ageless Fatherhood? Maybe Not

A man's biological clock ticks, too, researchers are discovering

By Kathleen Doheny
HealthDay Reporter

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SUNDAY, Feb. 18 (HealthDay News) -- Most women hoping to have a family are painfully aware of their biological clocks. They know their ability to bear children declines with age, even with all the innovation in fertility treatments.

Now, research is revealing that a man's potential for producing a child may not last forever, either -- at least not without health consequences for the child. And, as men age, those who don't take care of their health may fall victim to a faster, louder clock.

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"Men who are overweight, whose belly fat is very bad, have a higher chance of lower testosterone levels," reducing their ability to father a child, said Dr. Harry Fisch, director of the Male Reproductive Center and professor of clinical urology at Columbia University College of Physicians and Surgeons. Cigarette smoking can also adversely affect a man's fertility.

Fisch doesn't believe there's a "cutoff" point for fatherhood. "But the sooner, the better," he said, citing recent research.

Several studies have found that older fathers risk having children with medical problems, including Down syndrome. Fisch and his colleagues evaluated more than 3,400 cases of Down syndrome, finding that if the woman and the man were both over age 35 at the time of conception, the father's age played a role in prevalence of the disorder. This effect was most pronounced when the woman was over 40, the researchers found. And, in those cases, the incidence of Down syndrome was about 50 percent attributable to the sperm, the researchers said. The study was published in 2003 in The Journal of Urology.

In another study, Dr. Avraham Reichenberg, of Mount Sinai School of Medicine in New York City, found that advanced age for fathers is associated with an increased risk of autism. His team gathered data on the age of fathers of more than 318,000 people born in Israel during the 1980s. The researchers found that the chances of having a child with autism or a related disorder were about six times greater if the father was 40 or older, compared to men 29 or younger. The findings were published in the September 2006 issue of the Archives of General Psychiatry.

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