Blood Pressure Drugs May Fight Lung Cancer

Mouse study suggests ACE inhibitors shrink tumors

By Alan Mozes
HealthDay Reporter

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THURSDAY, March 15 (HealthDay News) -- Drugs commonly used to control high blood pressure may also shrink lung tumors, new animal studies show.

As prescribed, the medicines -- known as angiotensin-converting enzyme (ACE) inhibitors -- keep blood pressure in check by boosting levels of the "angiotensin (1-7)" hormone, thereby prompting dilation of blood vessel walls.

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Blood pressure patients taking ACE inhibitors also have lower rates of lung cancer, noted a team from Wake Forest University School of Medicine in Winston-Salem, N.C.

Investigating further, they found that angiotensin (1-7) cuts back on levels of cycloxygenase-2 (cox-2), an enzyme that promotes cell growth and is often elevated in lung cancer patients.

In the team's latest experiment, boosting angiotensin (1-7) levels in mice shrank lung cancer tumors by 30 percent.

"We are cautiously optimistic, but you know how these things go," said study co-author Patricia E. Gallagher, a researcher at Wake Forest's hypertension and vascular research center. "So many of these drugs go to trial, and while they work great in animals, when you get to the patient population, they're just not as effective. But to this point, we can say that, in mice, we got a reduction in cox-2 and a big reduction in tumor size without any toxic side effects."

The findings are reported in the March 15 issue of Cancer Research.

According to the American Cancer Society, lung cancer remains the leading cause of cancer death among men and women, killing more Americans than colon, breast, and prostate cancer combined. Because they are typically diagnosed at a later stage of disease, 6 in 10 lung cancer patients will die within the first year following diagnosis. Five-year survival is just 14 percent, and an estimated 170,000 Americans die each year from the disease.

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