More Than 5 Million Americans Now Have Alzheimer's

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Many experts believe that Alzheimer's is caused by a build-up of amyloid plaque proteins in the brain. But, again, the protein can only be detected through an autopsy.

Last week, scientists confirmed that an imaging agent known as Pittsburgh Compound B binds to beta-amyloid accumulations in the brain.

AV-1 was developed by a researcher at the University of Pennsylvania and is licensed exclusively by Avid. The new study was a joint effort between Austin Health, the University of Melbourne (Australia), Neuroscience Victoria (Australia), Avid, the University of Pennsylvania and Bayer Schering Pharma.

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The study involved five individuals with mild Alzheimer's disease and six healthy controls, all of whom underwent PET imaging over three hours after injection with AV-1. The PET imaging clearly distinguished patients with Alzheimer's from healthy individuals.

"This is basically the proof-of-concept stage," Carpenter said. "We will now need to go into phase 2 and phase 3 trials before submission of data to the FDA (U.S. Food and Drug Administration)."

AV-1 is one of three compounds that Avid has in clinical trials, he added. "Our goal is to select the compound with the best imaging properties within the next few months for multi-center clinical development studies and FDA approval," Carpenter said.

More information

Visit the Alzheimer's Association for more on this disease.

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