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Page: << Prev | 1 | 2 But there has not been much detailed research in patients who are at a high risk of cardiovascular problems and who are taking aspirin. Aspirin thins the blood and therefore reduces the risk of heart attacks and other cardiovascular events.
Previous studies have suggested that ibuprofen may interfere with aspirin's heart-healthy effects.
"Most of the data that's been generated in the past has been carried out in patients who do not have overt cardiac disease," explained Dr. Michael Farkouh, lead author of the study and director of the Mount Sinai Heart Clinical Trials in New York City. "We really have not studied cardiac patients that thoroughly."
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For this study, investigators revisited data on more than 18,000 individuals over the age of 50 with osteoarthritis, comparing the cox-2 inhibitor Prexige (lumiracoxib) with either ibuprofen or naproxen.
Ibuprofen and naproxen (brand name Aleve) are both traditional NSAIDs.
The study was funded by Novartis, the drug company that developed Prexige.
Ten percent of the participants were at high risk for a heart attack or stroke and some were taking low-dose aspirin (70 to 100 milligrams per day).
Individuals at low risk for cardiovascular disease had about the same number of heart attacks and strokes, regardless of which drug they were taking.
But high-risk patients taking aspirin and ibuprofen were about nine times more likely to have heart attacks and strokes over one year as those taking Prexige.
People taking ibuprofen were also more likely to develop congestive heart failure than those taking the cox-2 inhibitor.
The absolute risk of a problem was still low, with about 2.14 percent of those in the ibuprofen group suffering an event, versus 0.25 percent in the Prexige group.
The findings, if borne out, could be concerning, because ibuprofen is so easily available. "If cardiac patients take ibuprofen over-the-counter, that's a danger, because doctors aren't aware of it," Farkouh said. "It blocks the effect of aspirin, so there's more heart failure, more heart attacks, more hypertension. It's an important public health message."
More information
There's more on aspirin at the American Heart Association.
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